Recent Advances in Transition-Metal-Catalyzed, Directed Aryl C–H/N–H Cross-Coupling Reactions
نویسندگان
چکیده
Abstract Amination and amidation of aryl compounds using a transition-metal-catalyzed cross-coupling reaction typically involves prefunctionalization or preoxidation of either partner. In recent years, a new class of transition-metal-catalyzed cross-dehydrogenative coupling reaction has been developed for the direct formation of aryl C–N bonds. This short review highlights the substantial progress made for ortho-C–N bond formation via transition-metal-catalyzed chelation-directed aryl C–H activation and gives an overview of the challenges that remain for directed metaand para-selective reactions.
منابع مشابه
Transition-metal-catalyzed synthesis of phenols and aryl thiols
Phenols and aryl thiols are fundamental building blocks in organic synthesis and final products with interesting biological activities. Over the past decades, substantial progress has been made in transition-metal-catalyzed coupling reactions, which resulted in the emergence of new methods for the synthesis of phenols and aryl thiols. Aryl halides have been extensively studied as substrates for...
متن کاملInvestigations into Transition-Metal-Catalyzed Arene Trifluoromethylation Reactions Transition-Metal-Catalyzed Arene Trifluoromethylation Reactions
Trifluoromethyl-substituted arenes and heteroarenes are widely prevalent in pharmaceuticals and agrochemicals. As a result, the development of practical methods for the formation of aryl–CF3 bonds has become an active field of research. Over the past five years, transition-metal-catalyzed cross-coupling between aryl–X (X = halide, organometallic, or H) and various ‘CF3’ reagents has emerged as ...
متن کاملInvestigations into Transition Metal Catalyzed Arene Trifluoromethylation Reactions.
Trifluoromethyl-substituted arenes and heteroarenes are widely prevalent in pharmaceuticals and agrochemicals. As a result, the development of practical methods for the formation of aryl-CF3 bonds has become an active field of research. Over the past five years, transition metal catalyzed cross-coupling between aryl-X (X = halide, organometallic, or H) and various "CF3" reagents has emerged as ...
متن کاملModification of purine and pyrimidine nucleosides by direct C-H bond activation.
Transition metal-catalyzed modifications of the activated heterocyclic bases of nucleosides as well as DNA or RNA fragments employing traditional cross-coupling methods have been well-established in nucleic acid chemistry. This review covers advances in the area of cross-coupling reactions in which nucleosides are functionalized via direct activation of the C8-H bond in purine and the C5-H or C...
متن کاملPalladium-catalyzed decarboxylative acylation of O-methyl ketoximes with a-keto acids†
Aryl ketones are important structural motifs found in natural products, medicinally relevantmolecules, and functionalmaterials. In particular, 1,2-diacylbenzenes are known to be crucial synthetic precursors to construct a wide range of biologically active compounds including phthalazines, phthalimidines, isobenzofuranes, indanones, isoindoles, and isoindolines. These facts have led to increasin...
متن کامل